Physiologic Basis
The ABO antigen and antibodies remain the most significant for transfusion practice. The 4 blood groups A, B, O, and AB are determined by the presence of antigens A and B or their absence (O) on a patient’s red blood cells. Individuals possess antibodies directed toward the A or B antigen absent from their own red cells.
Interpretation
Type O patients can receive type O red cells and type A, B, O, or AB plasma. Type A patients can receive type A or O red cells and type A or AB plasma. Type B patients can receive type B or O red cells and type B or AB plasma. Type AB patients can receive type AB, A, B, or O red cells but only type AB plasma.In an emergency situation, type O red cells and type AB plasma may be given to patients with any ABO blood types.
Comments
For both blood donors and recipients, routine ABO typing includes both red cell and serum testing, as checks on each other. Tube testing is as follows: patient’s red cells are tested with anti-A and anti-B for the presence or absence of agglutination (forward or cell type), and patient’s serum or plasma is tested against known A and B cells (reverse or serum/plasma type).