Bilirubin Total, Direct & Indirect Report Format

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Tests included in Bilirubin Total, Direct & Indirect report:

Serum Bilirubin (Total)

Serum Bilirubin (Direct)

Serum Bilirubin (Indirect)

Bilirubin Total, Direct & Indirect Interpretation

In Labsmart software, this is the inbuilt interpretation for Bilirubin Total, Direct & Indirect

Physiological basis
Bilirubin is the orange-yellow pigment derived from the breakdown of hemoglobin (heme). The majority of bilirubin comes from senescent red cells. It is biotransformed in the liver and excreted in bile and urine.
The conjugated form is water soluble and reacts directly with diazo dyes in the absence of reaction accelerator, and is therefore called direct bilirubin. The unconjugated form is fat-soluble and reacts with diazo dyes only in the presence of accelerator; so it is called indirect.
Some conjugated bilirubin is bound to serum albumin, so-called D (delta) bilirubin.

Increased in: Acute or chronic hepatitis, cirrhosis, biliary tract obstruction, toxic hepatitis, neonatal jaundice (neonatal hyperbilirubinemia), congenital liver enzyme abnormalities (Dubin-Johnson, Rotor, Gilbert, Crigler-Najjar syndromes), fasting, hemolytic disorders. Hepatotoxic drugs.

Comments
Assay of total bilirubin includes conjugated (direct) and unconjugated (indirect) bilirubin. The unconjugated (indirect) form is the difference between total bilirubin (with reaction accelerator) and the direct bilirubin fraction. Delta bilirubin is determined together with conjugated bilirubin. Delta bilirubin (half-life is about 17 days) accounts for relatively slow regression of jaundice.
Only conjugated bilirubin appears in the urine, and it is indicative of liver disease and biliary tract obstruction.
Hemolysis is associated with increased unconjugated bilirubin. Unbound (free) serum or plasma bilirubin level correlates better than total bilirubin with CNS bilirubin concentrations and bilirubin encephalopathy (kernicterus) in newborn jaundice.

All inbuilt interpretations in the Labsmart pathology software is made in consultation with a doctor and is © copyright of Labsmart Healthcare Technologies.

Importance of adding interpretation to reports:

It's very helpful to add interpretation in reports as it makes the reports more patient friendly and also helpful to doctors in some cases. Moreover, presently most labs prefer providing reports with interpretation. Thus, adding interpretation to report will help your lab stay at par with other competitor labs.